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Dr. Mark Lange
.jpg) 509-335-3794
lange-m@wsu.edu
Assistant Professor,
Institute of Biological Chemistry. Ph.D. 1995, University of
Munich, Germany.
Lange laboratory website:
http://www.wsu.edu/~lange-m/index.html
Research
Plants produce a diverse array of metabolites, the
majority of which does not appear to be directly involved in growth
and development. These metabolites are commonly referred to as secondary
metabolites, specialized metabolites or natural products. In contrast
to primary metabolites, which are found in all plants and are usually
involved in essential processes (e.g., acyl lipids, amino acids,
chlorophylls, hormones, nucleotides, organic acids, phytosterols,
sugar phosphates, vitamins), natural products oftentimes play more
elusive roles in the communication of plants with their environment
(e.g., protection against herbivores and infection and attraction
of pollinators and/or seed dispersers) and are differentially distributed.
Plant natural products are better known for their utility as dyes
(e.g., indigo), fibers (e.g., cellulose), flavors (e.g., d-limonene
from Citrus), fragrances (e.g., geraniol from Damask rose), and
drugs (e.g., morphine). Research in the Lange laboratory is aimed
at characterizing the interface between primary and secondary metabolic
pathways using functional genomics and systems biology approaches.
Current projects:
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Crosstalk
between cytosolic and plastidial pathways of isoprenoid biosynthesis
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Metabolism in specialized cells (in particular: glandular
trichomes and soybean paraveinal mesophyll)
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Development of metabolite profiling assays
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Development of tools for the integration of post-genomic data
sets
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Development of mathematical models for metabolic pathways
Selected
publications
Lange, B.M. 2006. Biotechnology of isoprenoid production. In "Plant
Genetic Engineering Vol. 7: Metabolic Engineering & Molecular
Farming", Jaiwal, P.K. eds., pp 261-277.
Houston, TX: Studium Press LLC.
Lange B.M. 2006. Integrative analysis of metabolic
networks: From peaks to flux models? Curr. Op. Plant Biol. 9:220-226.
Mandaokar A., Thines B., Shin B., Lange B.M., Choi
G., Koo Y.J., Yoo Y.J., Choi Y.D., Choi G., Browse J. 2006. Transcriptional
regulators of stamen development in Arabidopsis identified by transcriptional
profiling. Plant J. 46:984-1008.
Ghassemian M., Lutes J., Tepperman J.M., Chang H.S., Zhu T., Wang
X., Quail P.H., Lange B.M. 2006. Integrative analysis of transcript
and metabolite profiling data sets to evaluate the regulation of
biochemical pathways during photomorphogenesis Arch. Biochem. Biophys.
448:45-59.
Lange B.M. 2005. Biotechnology of isoprenoid production. In Improving
the Nutritional and Therapeutic Qualities of Plants, Jaiwal, P.K.,
ed., Haworth Press Inc., New York, in press.
Lange B.M. 2005. Single-cell genomics. Curr. Op. Plant Biol. 8:236-241.
Lange B.M., Ghassemian M. 2005. Comprehensive post-genomic data
analysis approaches integrating biochemical pathway maps. Phytochemistry
66:413-451.
Browse J., Lange B.M. 2004. Counting the cost of a cold-blooded
life. Proc. Natl. Acad. Sci. USA 101:14996-14997.
Jenkins H., Hardy N., Beckmann M., Draper J., Smith A.R., Taylor
J., Fiehn O., Goodacre R., Bino R., Hall R., Kopka J., Lange B.M.,
Liu J.R., Mendes P., Nikolau B.J., Oliver S.G., Paton N.W., Roessner-Tunali
U., Saito K., Smedsgaard J., Sumner L.W., Wurtele E.S., Kell D.B.
2004. A proposed framework for the description of plant metabolomics
experiments and their results. Nature Biotechnol. 22:1601-1606.
Bino R.J., Hall R.D., Fiehn O., Kopka J., Saito K., Draper J.,
Nikolau B.J., Mendes P., Roessner-Tunali U., Beale M.H., Trethewey
R.N., Lange B.M., Wurtele E.S., Sumner L.W. 2004. Potential of
metabolomics as a functional genomics tool. Trends Plant Sci. 9:418-425.
Bick J.A., Lange B.M. 2003. Metabolic cross talk between cytosolic
and plastidial pathways of isoprenoid biosynthesis: unidirectional
transport of intermediates across the chloroplast envelope membrane.
Arch. Biochem. Biophys. 415:146-154.
Laule O., Führholz A., Chang H.S., Zhu
T., Wang X., Heifetz P.B., Gruissem W., Lange B.M. 2003. Crosstalk
between cytosolic and plastidial pathways of isoprenoid biosynthesis
in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 100:6866-6871.
Koller A., Washburn M.P., Lange B.M., Andon N.L., Deciu C., Haynes
P.A., Hays L., Schieltz D., Ulaszek R., Wei J., Wolters D., Yates
J.R. 2002. Proteomic survey of metabolic pathways in rice, Proc.
Natl. Acad. Sci. USA 99:11969-11974 (COVER STORY).
Goff S.A., Ricke D., Lan T.H., Presting G., Wang R., Dunn M.,
Glazebrook J., Sessions A., Oeller P., Varma H., Hadley D., Hutchison
D., Martin C., Katagiri F., Lange B.M. et al. 2002. A draft sequence
of the rice genome (Oryza sativa L. ssp. japonica), Science 296:92-100
(COVER STORY).
Lange B.M., Ketchum R.E.B., Croteau R. 2001. Isoprenoid biosynthesis:
metabolite profiling of peppermint oil gland secretory cells and
application to herbicide target analysis, Plant Physiol. 127:305-314.
Lange, B.M., Rujan, T., Martin, W., Croteau, R. 2000. Isoprenoid
biosynthesis: the evolution of two ancient and distinct pathways
across genomes, Proc. Natl. Acad. Sci. USA 97:13172-13177.
Lange B.M., Wildung M.R., Stauber E., Sanchez C., Pouchnik D.,
Croteau R. 2000. Probing essential oil biosynthesis and storage
by evaluation of expressed sequence tags from mint glandular trichomes,
Proc. Natl. Acad. Sci. USA 97:2934-2939.
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